Can I run gpt-oss 120B on an RTX 5080 (16 GB)?

Yes, with some experts in system RAM. MXFP4 keeps the expert weights of 29 of its 36 layers in RAM (about 46.4 GB of system RAM) and the rest on the GPU. That's the usual way to run a mixture-of-experts model bigger than the card, since only a few experts work on each token.

Every quant on RTX 5080

QuantSizeVRAM at 8K contextOn this card
MXFP459.0 GB15.2 GBexperts of 29/36 layers in RAM (46.4 GB)

Try it

How this is worked out

This is a prediction, not a benchmark. The quant sizes and the model's attention layout come from the real GGUF headers in ggml-org/gpt-oss-120b-GGUF (read 2026-11-01). VRAM counts every layer on the GPU, an f16 KV cache, about 0.7 GB of CUDA overhead, and about 0.5 GB already taken by the desktop. Speed isn't predicted here: it depends on far more than memory.

The same model on: RTX 3060, RTX 3060 Ti, RTX 3070, RTX 3080, RTX 3090, RTX 4060, RTX 4060 Ti 16GB, RTX 4070, RTX 4070 Super, RTX 4070 Ti Super, RTX 4080, RTX 4090, RTX 5060 Ti 16GB, RTX 5070, RTX 5070 Ti, RTX 5090, Radeon RX 7900 XTX, Radeon RX 9070 XT. Every model and card.